Overview
The present invention relates to a fully electronic biosensor for label free detection of DNA hybridization comprising low fixed-pattern noise (LFPN) capacitive trans-impedance amplifier (CTIA) coupled with a CMOS transistor. The invention works on the principle of semiconductor CMOS operation under the application of voltage detection converted by using various signal converters from the signal generated due to hybridization. No fluorescein or on chip gold electrode is required. A replaceable cavity for the DNA and the probe is used for multiple usage, higher precision, noise reduction and increased efficiency.